June 19,

2017

Biotype Innovation launches its first product line: A comprehensive FGFR panel

Dresden-Hellerau, June 19, 2017. Just two years after its foundation and a year after the lab inauguration, Biotype Innovation successfully launches its first four products. The company developed a unique FGFR panel (fibroblast growth factor receptor) allowing for the detection of various genetic alterations relevant to FGFR1, FGFR2, FGFR3, FGFR4, FGF3, FGF4, and FGF19 using the Modaplex platform. The FGFR panel comprises four multiplex assays based on polymerase chain reaction (PCR). These assays are used to detect copy number variations, gene fusions, mutations, and gene expressions.

FGFRs are signaling tyrosine kinase receptors that interact with 18 secreted FGF proteins. They are expressed in nearly all tissues and play essential roles in a wide range of physiological mechanisms. FGFR signaling has been reported many times to be dysregulated in several types of cancer through a variety of molecular mechanisms. Thus, various therapeutic approaches – for example, non-selective and selective tyrosine kinase inhibitors – are continuously evaluated through diverse clinical trials considering FGF and FGFR abnormalities.

The Biotype Innovation FGFR Analysis Kits support laboratories in addressing all their molecular testing requirements. The assays not only target the required FGFR genes, FGF genes, and their genetic aberrations but also provide the highest performance standards. In addition, the FGFR kits increase testing efficiency by enabling the detection of all genetic alterations simultaneously in just five hours. The workflow is as simple as that of a standard PCR.

These product launches mark the beginning of a wide product portfolio that Biotype Innovation will be developing for the Modaplex technology in the coming years. Further assays are currently under development and scheduled for launch later in 2017. They will be applicable in the area of precision medicine.

More detailed information on the FGFR panel is available in the FGFR brochure or on the Biotype Innovation website under the “Products-FGFR Assays” section.

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